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Sodium Valproate information from DrugsUpdate  

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Sodium Valproate, an anti-epileptic drug, is prescribed for the treatment of epilepsy in adults and children. Sodium Valproate can stabilize the brain’s electrical impulse in epileptic patients. Over stimulation or expression of electrical impulse results in seizures.

Pharmacodynamics

The mechanisms of action of Sodium Valproate are varying. The drug attenuates the Ca2+ dependent T current in brain, augments the release of inhibitory neurotransmitters such as GABA by inhibiting the metabolism and increase the biosynthesis. Similar to phenytoin, Sodium Valproate can acts on frequency-dependent prolongation of Na+ channel inactivation.

Pharmacokinetics

The oral absorption rate of Sodium Valproate is rapid and extensive. The Cmax is achieved within 1-4 hours of administration. About 90% of the administered drug is bound to plasma proteins. Sodium Valproate is extensively metabolized in liver via the oxidation, conjugation and glucuronidation process. The terminal half-life of Sodium Valproate is about 15 hours with sustained efficacy.

Sodium Valproate Indications / Sodium Valproate Uses

No information available

Sodium Valproate Adverse Reactions / Sodium Valproate Side Effects

Sodium Valproate can cause diarrhoea, transient hair loss, hyperactivity, aggression, increased alertness, GI irritation, weight gain, decreased platelet counts, weight gain, nausea, hyperacidity, hyperactivity, vasculitis, hyperammonaemia, tremors, behavioural changes, ataxia.

Rarely, Sodium Valproate can cause serious anaphylactic reaction, bleeding disorders, pancreatic problems, mood disorders, erythema-multiforme, jaundice-like reactions, bruising or bleeding tendency, abdominal pain due to pancreatitis or liver disorders and coma.

Precautions

Sodium Valproate is contraindicated in patients with porphyria, familial history of hepatic disorders including hyperammonaemia, SLE, renal disorders, immune disorders and diabetes mellitus. Sodium Valproate is contraindicated in children younger than three years of age.

Special Precautions

No information available

Other Drug Interactions

Sodium Valproate may interact with cholestyramine, cimetidine, aspirin, phenytoin, zidovudine, anticoagulants, MAOIs, aspirin, diazepam, anti-malarial drugs, temozolomide, erythromycin, meropenem, imipenem, carbamazepine, felbamate and anti-depressants.

Other Interactions

No information available

Dosage

For seizure (Adults):
Consider administration of 200 mg of Sodium Valproate, thrice daily. The dosage can be increased gradually based on tolerance and clinical response. The maximum dosage should not exceed 600 mg thrice daily.
 
For seizure (Pediatrics):
Consider administration of 10-15 mg/kg/day in three divided doses. The dosage of Sodium Valproate can be increased every week by 5 mg/kg/day. The maximum dose should not exceed 30-40 mg/kg/day.

Food(before/after)

No information available

List of Contraindications

Sodium Valproate and Pregnancy

Contraindicated in pregnancy
USFDA pregnancy category D. Sodium Valproate can harm the unborn fetus. Perform pregnancy tests before using Sodium Valproate. Use effective contraceptive mode to prevent unintended pregnancies while taking Sodium Valproate. The drug is contraindicated with second and third trimesters of pregnancy.

Sodium Valproate and Lactation

Sodium Valproate can pass through the breast milk and harm a nursing infant. Do not take Sodium Valproate unless prescribed by a physician.

Sodium Valproate and Children

The dosage and duration should be as prescribed by a pediatrician

Sodium Valproate and Geriatic

No information available

Sodium Valproate and Other Contraindications

No information available

Storage

No information available

Lab interference

No information available

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