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Pethidine information from DrugsUpdate  

See Available Brands of Pethidine in India

Pethidine, an opioid analgesic, is prescribed for the treatment of moderate to severe forms of pain. Pethidine is generally used as pre-operative and post-operative pain medication, labor pain and other forms of moderate to severe pains.


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Pethidine Indications / Pethidine Uses

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Pethidine Adverse Reactions / Pethidine Side Effects

Pethidine can cause nausea or vomiting, constipation, dizziness, nervousness, irritability, rashes, depression, hallucination, tremors, muscle twitches, convulsions, drowsiness, abdominal cramps, changes in urination frequency, anorexia, spincture muscle dysfunction, injection-site reactions and muscle spasm.


Pethidine should be used with caution in patients with Cor pulmonale, breathing difficulties, hypothyroidism, severe renal disease, neonates, biliary tract diseases, BPH, myasthenia gravis, convulsion, adrenocorticol insufficiency, shock and premature babies.

Pethidine is contraindicated in patients’ with elevated intracranial pressure, coma, head injuries, obstructive airway diseases, respiratory depression, Pethidine allergy, pheochromocytoma.

Do not use Pethidine within two weeks after MAOIs withdrawal.

Do not drive vehicle or operate heavy machineries while receiving Pethidine treatment.

Do not stop Pethidine treatment abruptly. It can cause serious withdrawal symptoms.

Special Precautions

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Other Drug Interactions

Pethidine may interact with cimetidine, anti-cholinergics, MAOIs, general anaesthesia, anxiolytics, hypnotics, phenothiazine, anti-depressants, analgesics and hypnotics.

Other Interactions

Do not consume alcohol while taking Pethidine. It may cause serious adverse events.


For moderate to severe acute pain (Adult):
Consider oral administration of 50-150 mg of Pethidine, every four hours.
As an adjunct to anaesthesia (Adults):
As an intravenous infusion, consider administration of 10-25 mg of Pethidine.
For moderate to severe acute pain (Adult):
As intravenous/subcutaneous/intra-muscular injections, consider administration of 25-100 mg of Pethidine, every four hours.
For obstetric analgesia (Adults):
As IV/IM/SC injection, consider administration of 50-100 mg of Pethidine, as soon as contractions occur. Administer at regular intervals of 1-3 hours. The maximum dose should not exceed 400 mg/day.
For pre-operative medication (Adults):
Consider administration of 25-100 mg of Pethidine one hour before surgery.
For post-operative pain (Adults):
Consider administration of 25-100 mg, every 2-3 hours, as needed.


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List of Contraindications

Pethidine and Pregnancy

USFDA pregnancy category D. Pethidine can harm the unborn fetus. Perform pregnancy tests before using Bosentan monohydrate. Use effective contraceptive mode to prevent unintended pregnancies while receiving Pethidine treatment.

Pethidine and Lactation

Pethidine may pass through the breast milk and harm a nursing infant. Do not breastfeed your baby while receiving Pethidine treatment.

Pethidine and Children

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Pethidine and Geriatic

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Pethidine and Other Contraindications

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Store at 15°- 25°C. Protect from light. Do not freeze

Lab interference

Store at 15°- 25°C. Protect from light. Do not freeze

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