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Iodine information from DrugsUpdate  

See Available Brands of Iodine in India

Iodine as oral and topical/cutaneous formulations is prescribed for the treatment of iodine deficiency disorders, pre-operative reduction of vascularity of thyroid glands, protection against radioactive iodine, cutaneous or lymphocutaneous sporotrichosis, Grave’s disease, cleaning of minor or superficial wounds, thyroid storm and cleaning of wet wounds and ulcers.

Pharmacodynamics

After administration of iodine, the element is converted into iodide for the synthesis of thyroid hormones. Topical application of iodine exerts irritant activity and as a microbicide against trichomonas, gram-positive, gram-negative bacteria, cysts, fungi including spore forming organisms and some viruses.

Pharmacokinetics

After oral administration, Iodine is slightly absorbed, transported and accumulated in thyroid gland tissues. After absorption, the drug is well-distributed in the body tissues and body fluids including breast milk. Iodine is excreted mostly via the urine; to some extent in sweat, saliva and feces.

Iodine Indications / Iodine Uses

No information available

Iodine Adverse Reactions / Iodine Side Effects

Iodine can cause fatal periarteritis, hypersensitivity reactions, ioderma, goitre, hypothyroidism, sialorrhoea, metallic taste with eye irritation.

Precautions

Iodine is contraindicated in renal impaired patients, tuberculosis infections, nodular goitre, hypocomplementemic vasculitis and acute bronchitis.

Special Precautions

No information available

Other Drug Interactions

Iodine can interact with potassium supplements, anti-thyroid drugs, lithium salts and potassium-sparing diuretics.

Other Interactions

No information available

Dosage

For Grave’s disease treatment (Pediatrics):
Administer one drop of strong iodine solution every eight hours.

For prophylaxis against radioactive iodine radiation
 (Adults):
Consider administration of 100-150 mg of Iodine, at least 24 hours before the procedure and daily up to ten, post-procedural.
 
For prophylaxis against radioactive iodine radiation (Pediatrics):
For neonates with predicted thyroid exposure of ≥5 centigrays (cGy), consider administration of 16 mg of oral iodine.
For infants over one month and children up to three years of age a predicted thyroid exposure of ≥5 cGy, consider oral administration of 32 mg of Iodine.
For children >3 yr and up to 18 yr with a predicted thyroid exposure of ≥5 cGy, consider oral administration of 65 mg of Iodine. The dose should exceed more than one dose/day.

For reduction of pre-operative vascularity of thyroid gland (Adults):
As oral potassium-iodide formulation, consider administration of 50-250 mg thrice daily for 10-14 days prior to surgical procedure.
 
For reduction of pre-operative vascularity of thyroid gland (Pediatrics):
As oral potassium-iodide formulation, consider administration of 50-250 mg thrice daily for 10-14 days prior to surgical procedure.
 
For treatment of lymphocutaneous or cutaneous sporotrichosis (Adults):
Administer 1 g of potassium iodide solution for one month and continue the treatment for one month after the disappearance of symptoms/lesions.
 
For treatment of lymphocutaneous or cutaneous sporotrichosis (Adults):
Administer 250 mg of potassium iodide solution thrice daily for three to six months.
 
For iodine deficiency disorders (Adults):
As an iodized oil, consider administration of 400 mg of iodine once years.
 
For iodine deficiency disorders (Pediatrics):
For infants up to one year of age, consider administration of 100 mg of Iodine as a single dose.
For children over one year and up to five years of age, consider administration of 200 mg of iodine.
For children over six years of age, consider administration of 400 mg of Iodine.
 
For treatment of thyroid storm (Adults):
Consider administration of 500 mg of potassium iodide every four hours.
 
For treatment of superficial and minor skin wounds (Adults/children):
Apply 2-2.5% of iodine solution or ointment, onto the affected area once or thrice a day.
 
For cleaning of wounds and wet ulcers (Adults):
Apply 0.9% of topical iodine gel onto the clean wound. The maximum dose should not exceed 50 g/application.

Food(before/after)

Oral Iodine formulations can be taken before or food intake

List of Contraindications

Iodine and Pregnancy

Contraindicated in pregnancy

USFDA pregnancy category D. Iodine can harm the unborn fetus. Perform pregnancy tests before using Iodine. Use effective contraceptive mode to prevent unintended pregnancies while taking Iodine.

Iodine and Lactation

Iodine can pass through the breast milk and cause adverse events in a nursing infant. Avoid using Iodine, if you are nursing mother.

Iodine and Children

Iodine should not be used in children unless prescribed by a pediatrician

Iodine and Geriatic

No information available

Iodine and Other Contraindications

No information available

Storage

No information available

Lab interference

No information available

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