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Thiabendazole information from DrugsUpdate  

See Available Brands of Thiabendazole in India

Thiabendazole, an anti-nematodal drug, is indicated for infections including cutaneous larva migrans, strongyloidiasis, dracunculiasis, ascariasis, toxocariasis, trichinosis, trichuriasis and trichostrongyliasis. The drug belongs to benzimidazole and triazole derivatives.

Pharmacodynamics

Thiabendazole is effective against nematode worms including its larval and ova stages. The drug inhibits the fumarate-reductase system of nematodes, the primary source of energy synthesis. The drug possesses the anti-fungal property.

Pharmacokinetics

After oral administration, Thiabendazole is rapidly absorbed in the GIT and skin. The peak plasma concentration can be achieved with in 1-2 hours. The drug is extensively metabolized in the liver. Thiabendazole is mostly excreted in the urine and in feces to some extent.

Thiabendazole Indications / Thiabendazole Uses

No information available

Thiabendazole Adverse Reactions / Thiabendazole Side Effects

Some of the commonly reported adverse events of Thiabendazole are hypotension, leucopenia, dizziness, dryness of mucus membrane, pruritus, dizziness, hypotension, enuresis, tinnitus, urine stones, bradycardia and abnormal LFTs. Rarely, Thiabendazole can cause liver damage, erythema multiforme, fatal Steven-Johnson syndrome and toxic epidermal necrolysis.

Precautions

Thiabendazole should not be used against mixed nematode infections such as Ascaris lumbricoides and enterobiasis. In some cases, Thiabendazole may impair vision. Do not drive vehicles or operate heavy machineries. Thiabendazole is contraindicated in patients with anemia, malnutrition, renal and/or hepatic disorders.

Special Precautions

No information available

Other Drug Interactions

Thiabendazole can interact with caffeine, theophylline and coumarins.

Other Interactions

No information available

Dosage

For Cutaneous larva migrans (Adults):
Start with an initial dose of 25 mg/day, twice daily for two or three days. The maximum dose should not exceed 3 g/day.
For Strongyloidiasis (Adults):
Start with an initial dose of 25 mg/day, twice daily for two or three days. Alternatively, 50 mg/kg as a single dose can be prescribed. The maximum dose should not exceed 3 g/day.
For Dracunculiasis (Adults):
Start with an initial dose of 25-50 mg/day, twice daily for five to eight days. Alternatively, 50 mg/kg as a single dose can be prescribed. The maximum dose should not exceed 3 g/day.
For Trichinosis (Adults):
Start with an initial dose of 25 mg/day, twice daily for two or four days. The maximum dose should not exceed 3 g/day.
For Toxocariasis (Adults):
Start with an initial dose of 25 mg/day, twice daily for five to seven days. The maximum dose should not exceed 3 g/day.
For Trichostrongyliasis (Adults):
Start with an initial dose of 25 mg/day, twice daily for two days. The maximum dose should not exceed 3 g/day.
For Trichuriasis (Adults):
Start with an initial dose of 25 mg/day, twice daily for two days. The maximum dose should not exceed 3 g/day.
For Ascariasis (Adults):
Start with an initial dose of 25 mg/day, twice daily for two days. The maximum dose should not exceed 3 g/day

Food(before/after)

Can be taken before or after food intake

List of Contraindications

Thiabendazole and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult a healthcare provider if you are in gestation or planning to have a baby during Thiabendazole treatment.

Thiabendazole and Lactation

It is not known whether Thiabendazole can pass through the breast milk or not. Breastfeeding mothers should avoid nursing while taking Thiabendazole.

Thiabendazole and Children

No information available

Thiabendazole and Geriatic

No information available

Thiabendazole and Other Contraindications

No information available

Storage

Store 15-30°C

Lab interference

Store 15-30°C

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