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Alfuzosin information from DrugsUpdate  

See Available Brands of Alfuzosin in India

L - Contraindicted in Lactation.

Alfuzosin is used to treat the signs and symptoms of benign enlargement of the prostate (benign prostatic hyperplasia or BPH). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems in urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely. Alfuzosin helps relax the muscles in the prostate and the opening of the bladder. This may help increase the flow of urine and/or decrease the symptoms.

Pharmacodynamics

Pharmacokinetics

Alfuzosin is a quinazoline-derivative which exhibits selectivity for α1-adrenergic receptors in the lower urinary tract. Blockade of these adrenoreceptors causes relaxation of smooth muscle in the bladder neck and prostate, resulting in improvement in urine flow and a reduction in symptoms of benign prostatic hyperplasia.

Absorption
Readily absorbed after oral admin.

Bioavaliability

about 64%.

Distribution

90% bound to plasma proteins.

Metabolism

Extensively metabolised in the liver, mainly by the cytochrome P450 isoenzyme CYP3A4, to inactive metabolites.

Excretion
About 11% excreted unchanged in urine. Metabolites are mainly excreted in faeces via bile.

Elimination half-life

About 3-5 hours

Alfuzosin Indications / Alfuzosin Uses

Information Not Available

Alfuzosin Adverse Reactions / Alfuzosin Side Effects

Drowsiness, postural hypotension, syncope, asthenia, depression, headache, dry mouth, GI disturbances, edema, blurred vision, rhinitis, erectile disorders, tachycardia, palpitation, hypersensitivity reactions; flushes; chest pain; dizziness; lack of energy.

Precautions

This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. The patient needs to make sure of they know how they would react to this medicine before driving, usage of machinery, or do anything else that could be dangerous if dizzy or not alert .

Special Precautions

Elderly; hypertension; coronary insufficiency; angina (discontinue); renal or hepatic impairment. Monitor BP regularly. May affect ability to drive or operate machinery.

Other Drug Interactions

CYP3A4 inhibitors e.g. azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, telithromycin, and verapamil may increase the levels of alfuzosin. Reduced serum levels when used with CYP3A4 inducers e.g. aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin and rifamycins.


Potentially Fatal: Concurrent use with potent CYP3A4 inhibitors (e.g. itraconazole, ketoconazole or ritonavir) is contraindicated.

Other Interactions

Information Not Available

Dosage

Oral
Benign prostatic hyperplasia
Adult: 2.5 mg tid. Max dose: 10 mg daily.
Elderly: Initially, 2.5 mg bid.

Renal impairment: Initiate with 2.5 mg bid. Adjust dose according to response.
Hepatic impairment: Mild-moderate impairment: Initiate with 2.5 mg daily, may increase to 2.5 mg bid gradually according to response. Modified-release preparations are not recommended.

Food(before/after)

Should be taken with food.

List of Contraindications

Alfuzosin and Pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Alfuzosin and Lactation

Contraindicted in Lactation.

Alfuzosin and Children

Information Not Available

Alfuzosin and Geriatic

Information Not Available

Alfuzosin and Other Contraindications

Severe hepatic impairment; history of postural hypotension and micturition syncope; intestinal occlusion; severe renal insufficiency; lactation.

Storage

Store between 15-30°C.

Lab interference

Store between 15-30°C.

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