Flupirtine maleate information from DrugsUpdate
Flupirtine, a non-opioid analgesic, is indicated for the management of moderate to severe forms of acute and chronic pain including migraine, dysmenorrhoea, post-traumatic pain, post-surgical pain and injuries. Flupirtine possess moderate muscle relaxant property.
Flupirtine is a centrally-acting and non-opioid analgesic. The drug activates G-protein-coupled receptors that stimulate K+ channels of neuronal cells. The drug acts as an indirect N-methyl-D-Aspartate (NMDA) antagonist. Flupirtine inhibits neuronal excitability and reduce calcium Ca2+ influx into the cells. The mechanism is vital for neuronal transmission of pain signals to motor neurons.
After oral absorption, Flupirtine is well absorbed in the GIT. The apparent Vss of Flupirtine is about 150 L. The Cmax is about 1.5-2 hours after oral administration. Flupirtine is metabolized by the liver. The drug is excreted by biliary route as drug metabolites. The terminal half-life is about 7 hours.
Flupirtine is contraindicated in patients with hepatic encephalopathy, cholestasis, myasthenia gravis and ataxia.
Flupirtine may interact with other drugs including sedatives, hypnotics, anticoagulants and benzodiazepines.
Do not consume alcohol while taking Flupirtine. It can increase the adverse events of Flupirtine.
For pain (Adults):
Start with an initial oral dose of 200 mg/day. The dosage can be titrated to 100 mg, thrice daily, depending on pain intensity.
For pain (Pediatrics):
For children over six years, consider oral administration of 50 mg, thrice or four times a day.
For renal-impaired patients:
The dosage should be reduced by 50% of the recommended adult dosage.
Can be taken before or after meals intake
List of Contraindications
Flupirtine has not been classified under USFDA pregnancy category. However, caution should be exercised before taking Flupirtine during pregnancy.
Nursing mothers should consult a physician before taking Flupirtine.
Store in a cool and dry place protected from light and moisture