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Ursodeoxycholic Acid information from DrugsUpdate  

See Available Brands of Ursodeoxycholic Acid in India

P - Contraindicated in pregnancy
L - Caution when used during lactation

Ursodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria.

Pharmacodynamics

Pharmacokinetics

Ursodeoxycholic acid suppresses hepatic synthesis and secretion of cholesterol and also inhibits intestinal absorption of cholesterol.

Absorption
Rapidly and completely absorbed from the GI tract.

Distribution
Protein binding: 96-98%. Undergoes enterohepatic recycling.

Metabolism
Partly conjugated in the liver before being excreted into the bile. Free and conjugated forms undergo 7a-dehydroxylation to lithocholic acid under the influence of gut bactera. Some are reabsorbed and then further conjugated and sulfated by the liver.

Excretion
Faeces.

Ursodeoxycholic Acid Indications / Ursodeoxycholic Acid Uses

Information Not Available

Ursodeoxycholic Acid Adverse Reactions / Ursodeoxycholic Acid Side Effects

Diarrhoea, pruritus, nausea, vomiting, gallstone calcification.

Precautions

Information Not Available

Special Precautions

50% of successfully treated patients will develop further gallstones within 10 yr. Lactation.

Other Drug Interactions

Cholestyramine, charcoal and antacids may reduce effectiveness. Aluminum-based antacids may reduce absorption. Oestrogens and clofibrate may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile. Possible increase in ciclosporin serum concentration. Decreased effectiveness of dapsone. Possible decrease in serum ciprofloxacin and nitrendipine.

Other Interactions

Information Not Available

Dosage

Oral
Dissolution of cholesterol-rich gallstones
Adult: 6-12 mg/kg daily as a single dose at bedtime or in 2-3 divided doses continued for 3-4 mth after radiological disappearance of stones. Doses may be divided unequally with a higher dose given before bedtime to counteract increase in biliary cholesterol saturation which occurs in early morning. Max: 15 mg/kg.
Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution.

Oral
Primary biliary cirrhosis
Adult: 10-15 mg/kg daily in 2-4 divided doses.

Oral

Prevention of gallstones in patients undergoing rapid weight loss
Adult: 300 mg bid.
Hepatic impairment: Chronic liver disease (except primary biliary cirrhosis): use with caution.

Food(before/after)

Should be taken with food

List of Contraindications

Ursodeoxycholic Acid and Pregnancy

Contraindicated in pregnancy.


Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Ursodeoxycholic Acid and Lactation

Caution when used during lactation

Ursodeoxycholic Acid and Children

Information Not Available

Ursodeoxycholic Acid and Geriatic

Information Not Available

Ursodeoxycholic Acid and Other Contraindications

Calcified and pigment gallstones, radio opaque gallstones. Nonfunctioning gall bladders; chronic liver and peptic ulcer disease. Inflammatory disease of colon and small intestine. Pregnancy.

Storage

Information Not Available

Lab interference

Information Not Available

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