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Acebrophylline information from DrugsUpdate  

See Available Brands of Acebrophylline in India

Acebrophylline, a xanthine derivative, is prescribed as a bronchodilator for the treatment of bronchial asthma and COPD in adults. Acebrophylline alter mucus gel secretion phase by lowering viscosity and increasing the serous gel phase. By augmenting ciliary motility, Acebrophylline increases the mucociliary clearance.

Pharmacodynamics

Acebrophylline inhibits intracellular phosphodiesterase associated with cAMP levels and facilitates bronchial muscles relaxation. Acebrophylline selectively inhibits phosphatidylcholine and phospholipase A, TNF-alpha and leukotrienes. Inhibition of such pro-inflammatory mediators can significantly reduce the airway inflammation and obstruction in chronic stages.

Pharmacokinetics

After oral administration, the drug is rapidly absorbed in the stomach and Cmax can be reached within two hours. The plasma half-life of Acebrophylline varies from 4-9 hours. The drug is primarily metabolized in the liver and eliminated via the urine.

Acebrophylline Indications / Acebrophylline Uses

No information available

Acebrophylline Adverse Reactions / Acebrophylline Side Effects

Acebrophylline can cause glycosuria, epigastric pain, low blood pressure, GI discomfort or distension, anorexia, drowsiness, breathing difficulties, albuminuria, hyperglycemia, leucocytosis, mild skin reactions, fever, fatigue and nasal inflammation.

Precautions

Acebrophylline is contraindicated in patients with hypotension, acute myocardial infarction, impaired hemodynamics, hepatic or/and renal disorders, Ambroxol allergy, GI disorders, convulsion, arrhythmia, CAD, cardiac insufficiency and hyperthyroidism.

Special Precautions

No information available

Other Drug Interactions

Acebrophylline should not be prescribed concomitantly with lincomycin, clindamycin, erythromycin, allopurinol, barbiturates, quinolone derivatives, oxytetracycline, cimetidine, furosemide, anticoagulants, oligomycin, phenytoin and reserpine.

Other Interactions

No information available

Dosage

For COPD and bronchial asthma (Adults):
Consider administration of 100 mg of Acebrophylline, twice daily.

Food(before/after)

Acebrophylline can be preferably taken after meals to avoid GI discomfort.

List of Contraindications

Acebrophylline and Pregnancy

No information available about USFDA pregnancy category. However, Acebrophylline is contraindicated in pregnancy.

Acebrophylline and Lactation

Nursing mothers should consult a physician before taking Acebrophylline

Acebrophylline and Children

No information available

Acebrophylline and Geriatic

No information available

Acebrophylline and Other Contraindications

No information available

Storage

Store at room temperature, 15-30° C (59-86°F). Keep away from moisture

Lab interference

Store at room temperature, 15-30° C (59-86°F). Keep away from moisture

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