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Dihydrocodeine information from DrugsUpdate  

See Available Brands of Dihydrocodeine in India

Dihydrocodeine, an opioid analgesic, is generally prescribed for as a painkiller and cough suppressant.

Pharmacodynamics

Dihydrocodeine binds with opioid receptors in the brain and spinal cord tissues that result in inhibition of pain signals by alterations of perception and pain response. Synthetic opioids mimic the structure and action of endorphins – a natural pain-killing biochemical. The direct action of Dihydrocodeine acts on the medullary region results in central suppression of cough.

Pharmacokinetics

No information available

Dihydrocodeine Indications / Dihydrocodeine Uses

No information available

Dihydrocodeine Adverse Reactions / Dihydrocodeine Side Effects

Dihydrocodeine can cause hypothermia, drowsiness, confusion, vomiting, nausea, constipation, CNS effects, elevated intracranial pressure, muscle rigidity, pulmonary edema, hypotension and respiratory depression. Some of the fatal adverse events of Dihydrocodeine are circulatory failure and coma.

Precautions

Dihydrocodeine is contraindicated in patients with traumatic injuries, raised intracranial pressure, hypersensitivity, hypothyroidism, myasthenia gravis, hypotension, prostate hyperplasia, adrenocortical insufficiency, obstructive pulmonary disorders, comatose patients and chronic alcoholics.
Dihydrocodeine may impair thinking and mental alertness. Do not drive vehicles or operate heavy machineries while taking Dihydrocodeine.

Special Precautions

No information available

Other Drug Interactions

Dihydrocodeine can interact with MAOIs, cyclizine, anaesthetic drugs, anxiolytics, alcohol, other narcotic drugs, hypnotics, cisapride, metoclopramide, domperidone, tricyclic anti-depressants and anti-psychotic drugs.

Other Interactions

No information available

Dosage

Oral
For Analgesia (Adults):
Consider oral administration of 30 mg of Dihydrocodeine, every 4-6 hours. The maximum dose should not exceed 240 mg/day.
For Analgesia (Adults):
For children >4 years of age, consider administration of 0.5-1.0 mg/kg, every 4-6 hour.
As a Cough suppressant (Adult):
Consider administration of 10-30 mg of Dihydrocodeine, thrice daily.

Food(before/after)

Dihydrocodeine should be taken with food

List of Contraindications

Dihydrocodeine and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn fetus. Consult a physician if you are in gestation or planning to have a baby during Dihydrocodeine treatment.

Dihydrocodeine and Lactation

It is not known whether Dihydrocodeine can pass through the breast milk or not. Breastfeeding mothers should avoid nursing while taking Dihydrocodeine.

Dihydrocodeine and Children

No information available

Dihydrocodeine and Geriatic

No information available

Dihydrocodeine and Other Contraindications

No information available

Storage

No information available

Lab interference

No information available

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