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Dextrose information from DrugsUpdate  

See Available Brands of Dextrose in India

Dextrose injection is indicated as a source of calories and water in patients with hypoglycemia and hyperkalemia. Dextrose, a monosaccharide form of glucose improves hydration in such patient and reduces body protein loss and nitrogen. Dextrose promotes gluconeogenesis. If administered concomitantly with insulin, Dextrose facilitates cellular uptake of potassium in tissues and thereby reduce circulatory levels of potassium.

Pharmacodynamics

No information available

Pharmacokinetics

Dextrose is rapidly absorbed in the duodenum if administered as oral formulation. Dextrose is rapidly metabolized to water and carbon dioxide.

Dextrose Indications / Dextrose Uses

No information available

Dextrose Adverse Reactions / Dextrose Side Effects

Dextrose can cause tachypnoea, increased thirst, hypovolemia, dehydration, hyperosmolar syndrome, acidosis, hypokalemia, hypomagnesemia, increased micturition, thrombophlebitis, pulmonary edema, diarrhoea, ketonuria and glycosuria.

Precautions

Dextrose is contraindicated in patients with corn or corn products allergy, diabetic coma with elevated blood glucose, intraspinal hemorrhage, dehydrated patients, hepatic coma and galactose malabsorption syndrome.
Dextrose should not be prescribed to patients with carbohydrate intolerance, subclinical diabetes mellitus, salt imbalance and risk of thrombosis.

Special Precautions

No information available

Other Drug Interactions

No information available

Other Interactions

No information available

Dosage

Oral:
For Hypoglycaemia (Adult):
Consider administration of 10-20 g of Dextrose as single dose. The dosage can be repeated within ten minutes, if required.
For Hypoglycemia (Pediatric):
For children >2 years, consider administration of 10-20 g of Dextrose as a single dose. The dosage can be repeated within ten minutes, if needed.
 
Intravenous
For Hypoglycaemia (Adults):
Consider administration of -100 ml of 25% Dextrose solution or 20-50 ml of 50% Dextrose solution (10-25 g of Dextrose) as a single dose. The dosage can be repeated, if required.
 
For Hypoglycemia (Pediatric):
For children ≤6 months and >6 months of age, consider administration of 0.25-0.5 g/kg/dose and 0.5-1 g/kg/dose, respectively. The dosage can be repeated, if needed. The maximum dosage should not exceed 25 g/dose.
Intravenous

For Hyperkalaemia (Adults):
Consider administration of 25-50 g of Dextrose as a combined therapy with regular insulin (10 units) as an intravenous infusion over 30-60 minutes. The dose can be repeated, if needed.
 
For Hyperkalemia (Pediatric):
Consider administration of 25% or 50% of Dextrose solution (0.5-1 g/kg) as a combined therapy with insulin (1 unit/4-5 g dextrose). The mixture should be administered as an intravenous infusion over two hours, and can be repeated, if needed.

Food(before/after)

Oral formulations should be given on an empty stomach, at least one or two hours before meals.

List of Contraindications

Dextrose and Pregnancy

No information available

Dextrose and Lactation

No information available

Dextrose and Children

No information available

Dextrose and Geriatic

No information available

Dextrose and Other Contraindications

No information available

Storage

Intravenous: Store at 25°C. Oral: Store at 25°C.

Lab interference

Intravenous: Store at 25°C. Oral: Store at 25°C.

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