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Bromelain information from DrugsUpdate  

See Available Brands of Bromelain in India

Bromelain, a naturally occurring phytoenzyme is present in pineapple and pineapple juice. Bromelain is generally prescribed for the treatment of osteoarthritis, inflammation, hay fever, ulcerative colitis, debridement and shortening of labor. Bromelain can help muscle relaxation, improve antibiotic absorption and prevent cancer.
Bromelain is generally available as Bromelain with trypsin and rutin formulations.

Pharmacodynamics

Bromelain reduces inflammation by interfering with the enzymatic synthesis involved in Arachidonic acid metabolic pathway. Inhibition of such enzymes results in increased bleeding time and prevention or reduced inflammation. Bromelain can interfere with growth of malignant cells by unknown mechanisms.

Pharmacokinetics

No information available

Bromelain Indications / Bromelain Uses

No information available

Bromelain Adverse Reactions / Bromelain Side Effects

Bromelain can cause bleeding tendency, easy bruising and increased clotting time. In certain cases, Bromelain can cause diarrhoea and other GI discomfort.

Precautions

Bromelain is contraindicated in patients who are allergic to pineapple, carrot, fennel, grass pollen, cypress pollen, celery and synthetic Bromelain products/supplements. Bromelain should not be given to patients who need to undergo surgery within two weeks. Stop taking Bromelain at least two weeks prior to a scheduled surgery to avoid bleeding risks.

Special Precautions

No information available

Other Drug Interactions

Bromelain may interact with amoxicillin, tetracycline group of antibiotics, anticoagulants, anti-platelet drugs including NSAIDs.

Other Interactions

As a phytoproduct, Bromelain may interact with angelica, aniseed, ginger, asafoetida, celery, chamomile, alfalfa, fenugreek, willow, red clover, licorice, chestnut, poplar, quassia, zinc, potato and soybean.

Dosage

For Osteoarthritis (Adults):
Consider administration of 2 tablets, thrice daily.

Food(before/after)

Bromelain can be taken before or after food intake

List of Contraindications

Bromelain and Pregnancy

No information available

Bromelain and Lactation

It is not known whether Bromelain can pass through the breast milk or not. Breastfeeding mothers should avoid nursing while taking Bromelain.

Bromelain and Children

No information available

Bromelain and Geriatic

No information available

Bromelain and Other Contraindications

Information not available

Storage

Store below 25°C. Protect from light.

Lab interference

Store below 25°C. Protect from light.

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