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Tapentadol information from DrugsUpdate  

See Available Brands of Tapentadol in India

Tapentadol, a narcotic analgesic, is prescribed for the treatment of moderate to severe forms of pain.


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Tapentadol Indications / Tapentadol Uses

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Tapentadol Adverse Reactions / Tapentadol Side Effects

Tapentadol can cause increased sweating, agitation, hallucination, severe dizziness, drowsiness, convulsion, constipation, itching, dry mouth, confusion, problems with speech and balance, overactive reflexes, nausea, vomiting and fainting. Tapentadol can cause habit-forming and addiction.


Tapentadol should not be prescribed to individuals with history of alcohol and/or substance abuse.

Special Precautions

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Other Drug Interactions

Tapentadol may interact with other narcotic analgesics, sedatives, muscle relaxants, anti-convulsant drugs, anti-depressants, anxiolytics, anti-histamines and sleep-inducing drugs.

Other Interactions

Consumption of alcohol while taking Tapentadol may cause serious adverse events.


For Pain (Adults):
As an immediate-release formulation, Tapentadol can be prescribed as 50 mg, 75 mg or 100 mg oral dose, every 4-6 hours, as needed. The maximum daily dose should not exceed 700 mg.
As an extended-release, start with 50 mg twice daily. The dosage can be increased based on titrated doses, up to 100-250 mg/day. The maximum dose should not exceed 500 mg/day.

For individuals who are previously treated with opioid drugs, start with an initial dose of 50 mg with titrated increment of 50 mg, twice daily for every three days. The therapeutic dose range should be 100-250 mg, twice daily. The maximum daily dose should not exceed 500 mg/day.
For switching over from immediate-release to extended-release formulation, prescribe the same daily dose in (two) equal divided doses. The maximum dose should not exceed 500 mg/day.


Tapentadol can be taken before or after food intake

List of Contraindications

Tapentadol and Pregnancy

USFDA Category C: Tapentadol may be or may not be harmful to an unborn fetus. Consult a physician if you are in gestation or planning to have a baby during treatment. Gestational administration of Tapentadol increase risk of premature delivery and decreased baby weight with symptoms of withdrawal symptoms in infants.

Tapentadol and Lactation

Tapentadol can pass to the infant through breast milk. Tapentadol treatment should be avoided in nursing mothers

Tapentadol and Children

Tapentadol is contraindicated in children.

Tapentadol and Geriatic

Elderly individuals are more sensitive to adverse events of Tapentadol

Tapentadol and Other Contraindications

Information not available


Store at 20-25°C.

Lab interference

Store at 20-25°C.

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