Drugsupdate.com is up for sale. To own one of the most recognized online brands by doctors in India with millions of visitors - click here.

logo image

Silodosin information from DrugsUpdate  

See Available Brands of Silodosin in India

Silodosin, an alpha adrenergic blocker, is prescribed for the treatment of benign prostatic hyperplasia (BPH). The drug aids relaxation of prostate and bladder neck muscles and facilitates micturition.

Pharmacodynamics

Silodosin is a selective blocker of post-synaptic alpha-1 adrenergic receptors in bladder base, prostate, prostate urethra, bladder neck and prostatic capsule. Selective blocking of such receptors results in smooth muscle relaxation and facilitated urine flow with reduction of BPH symptoms.

Pharmacokinetics

The oral bioavailability of Silodosin is about 32%. The absorption rate is affected by moderate fat and calorie meals. The apparent Vss of Silodosin is 49.5 L, and about 97% of the drug is bound to plasma proteins. The drug is primarily metabolized by hepatic enzymes including cytochrome P450 pathway. Silodosin is excreted by urine and feces.

Silodosin Indications / Silodosin Uses

Information not available

Silodosin Adverse Reactions / Silodosin Side Effects

Silodosin can cause painful penile erection that may last over four hours, abnormal ejaculation, rhinorrhoea, headache, diarrhoea, dizziness and fainting.

Precautions

Silodosin may impair thinking and mental alertness. Do not drive vehicles or operate heavy machineries while taking Silodosin. Avoid going out in the hot sun or in extreme weather conditions, it may lead to serious dehydration. Do not wake up fast from bed in the morning. It may cause fall accident. Silodosin is contraindicated in patients with severe hepatic or renal disorders.
An adjusted dosage may be needed for patients with prostate malignancy, hepatic and renal disorders. Avoid using Silodosin at least before or after cataract surgery.

Special Precautions

Information not available

Other Drug Interactions

Silodosin may interact with quinidine, imatinib, conivaptan, INH, anti-fungal drug, clarithromycin, erythromycin, anti-depressants, calcium channel blockers, sildenafil, immunosuppressive drugs and quinidine.

Other Interactions

Do not consume alcohol while taking Silodosin

Dosage

For Benign Prostatic Hyperplasia (Adults):
The recommended oral dosage is 8 mg/day.

Food(before/after)

Silodosin should be preferably taken with meals.

List of Contraindications

Silodosin and Pregnancy

No information available

Silodosin and Lactation

No information available

Silodosin and Children

Silodosin is contraindicated in children

Silodosin and Geriatic

No information available

Silodosin and Other Contraindications

No information available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

© 2011-2018 DrugsUpdate.com. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.