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Rho(D) information from DrugsUpdate  

See Available Brands of Rho(D) in India

Rho(D), a humanized immunoglobulin protein, is used to prevent the immune response to Rh positive serotypes in Rh negative blood type individuals that results in erythroblastosis fetalis (Type II hypersensitivity). Rho(D) can also be used to treat the immune system-induced thrombocytic purpura (ITP). However, RhoD should not be used for the treatment of immunological disorder associated with immune incompatibility.

Pharmacodynamics

RhoD human lowers immunoglobulin response against the Rh-positive red blood cells of Rh-negative individuals.

Pharmacokinetics

No information available

Rho(D) Indications / Rho(D) Uses

No information available

Rho(D) Adverse Reactions / Rho(D) Side Effects

Consult a physician if symptoms of allergy develop. Rho(D) can cause pale skin, troubled concentration, easy bruising, rapid breathing, itching, nausea, diarrhoea, fatigue, chills, tremors, dark-coloured urine, urination changes, weight gain and injection-site reactions.

Precautions

Rho(D) is contraindicated in patients with synthetic immunoglobulin allergy, haemolytic anemia patients, heart disease patients, hemophilia and dyslipidemia patients.

Special Precautions

No information available

Other Drug Interactions

No information available

Other Interactions

No information available

Dosage


For Idiopathic (Immune) Thrombocytopenic Purpura (Adults):

Start with an initial dose of 50 mcg/kg body weight, IV, once. The duration and dosage can be decided based on the clinical response. For the maintenance therapy, consider administration of 25-60 mcg/kg and adjust the dose based on the platelet and hemoglobin levels.
 
For Rh-Isoimmunization (Adults):
The dosage and route of administration differs with each brands.
 
For Idiopathic (Immune) Thrombocytopenic Purpura (Pediatric):
Start with an initial dose of 50 mcg/kg body weight, IV, once. If needed, the dosage can be given as two divided doses. For maintenance dose, consider administration of 25-60 mcg/kg body weight, and the dosage and duration can be increased based on the RBC, Hb, platelets and reticulocyte levels, as needed.

Food(before/after)

No information available

List of Contraindications

Rho(D) and Pregnancy

No information available

Rho(D) and Lactation

No information available

Rho(D) and Children

No information available

Rho(D) and Geriatic

No information available

Rho(D) and Other Contraindications

No information available

Storage

Should be stored in the refrigerator. Do not freeze.

Lab interference

Should be stored in the refrigerator. Do not freeze.

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