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Ranolazine information from DrugsUpdate  

1
See Available Brands of Ranolazine in India

Ranolazine, an anti-anginal drug, is prescribed for the prevention of angina. The drug augments the hemodynamics and improves heart out. Ranolazine should not be used to treatment an acute anginal attack.

Pharmacodynamics

The effect of Ranolazine on mean systolic BP and heart rate is minimal.

Pharmacokinetics

No information available

Ranolazine Indications / Ranolazine Uses

No information available

Ranolazine Adverse Reactions / Ranolazine Side Effects

Ranolazine can cause bruising, skin rashes, muscle weakness, arrhythmia, hematuria, tremors, shortness of breath, edema in the lower extremities, tremors, numbness, dry mouth, abdominal pain, constipation, vertigo, headache, dizziness, tinnitus and constipation.

Precautions

Ranolazine may impair thinking and alertness. Do not drive vehicles or operate heavy machineries while taking Ranolazine. The drug is contraindicated in patients with QT prolongation.

Special Precautions

No information available

Other Drug Interactions

Ranolazine may interact with dexamethasone, arsenic trioxide, digoxin, fluconazole, tamsulosin, chloroquine, lovastatin, fluoroquinolones, statins, tolterodine, anti-depressant drugs, anti-ADHD drugs, anti-fungal drugs, anti-cancer drugs, anti-tussives, anti-emetics, amiodarone, beta-blockers, chlorpromazine, phenergan, pimozide, haloperidol, cyclosporine, zolmitriptan, sumatriptan, methadone, codeine, morphine and tramadol.

Other Interactions

Avoid consuming grapefruit, wine or grapefruit juice while taking Ranolazine. It may cause serious drug reactions.

Dosage

Start with an initial dose of 500 mg twice daily. The dosage can be increased to 1000 mg twice daily, if needed.

Food(before/after)

Ranolazine can be taken before or after food intake

List of Contraindications

Ranolazine and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult your doctor if you are in gestation or planning to have a baby during Ranolazine treatment.

Ranolazine and Lactation

It is not known whether Ranolazine can pass through the breast milk or not. Nursing mothers should avoid breastfeeding while taking Ranolazine.

Ranolazine and Children

No information available

Ranolazine and Geriatic

No information available

Ranolazine and Other Contraindications

No information available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

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