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Imiquimod information from DrugsUpdate  

See Available Brands of Imiquimod in India

Imiquimod is prescribed for the treatment of actinic keratosis on the face and scalp, superficial basal cell carcinoma and genital warts. Imiquimod is an immune response modifying drug that is indicated in adults and children over 12 years of age.

Pharmacodynamics

Imiquimod increase the levels of biomarkers such as CD3, CD4, CD8, CD11c and CD68 in patients with actinic keratosis. Imiquimod increase lymphocytic infiltration, dendritic cells and macrophage in the tumor lesions of superficial basal cell carcinoma. Imiquimod induces mRNA encoding cytokines including interferon-alpha in the treated area in external genital warts patients. However, no anti-viral properties are observed in the clinical trials.

Pharmacokinetics

No information available

Imiquimod Indications / Imiquimod Uses

Information not available

Imiquimod Adverse Reactions / Imiquimod Side Effects

In case of serious skin reactions such as oozing, bleeding or itching, wash off the applied medicine, and discontinue Imiquimod use. Imiquimod can cause severe swelling, urination problems, cold sores, fever, blisters, vaginal discharge, nausea, diarrhoea, blisters, changes in treated skin, mild skin irritation, flaking, scabbing, crusting, hardening and dryness.

Precautions

Imiquimod is contraindicated in patients with autoimmune disorders, immune dysfunctions, sunburns, skin problems, organ transplanted patients, GVHD. Imiquimod should not be prescribed in patients who were recently treated with actinic keratosis or genital warts with surgery.


Avoid application of Imiquimod with lips, eyes, mouth or nose. Do not apply Imiquimod on rectum, urethra, irritated skin, sunburns and vagina. Avoid direct exposure to sunlight while using Imiquimod. Avoid unprotected sex.

Special Precautions

No information available

Other Drug Interactions

No information available

Other Interactions

No information available

Dosage

For Keratosis (Adults):
Apply a thin layer (3.75% cream, up to 0.5g) of Imiquimod cream onto the affected area once a day before bedtime. The treatment should be continued at least for two weeks with an interval for 2 weeks, and then Imiquimod treatment should be continued.
If 5% cream is prescribed, apply Imiquimod topical cream onto the affected area twice per week, before bedtime. The treatment area should not be more than 5x5 cm. The treatment should be continued for 16 weeks.
If 2.5%, 3.75% and 5% creams are prescribed, a thin layer of topical cream should be applied onto the affected area, and rubbed gently. The layer should be left untouched for at least 8 hours.

For Condylomata Acuminata (Adults):
Apply a thin layer (3.75% cream, up to 0.5g) of Imiquimod cream to external genital/perianal warts area once a day before bedtime. The treatment should be continued at least for two weeks with an interval for 2 weeks, and then Imiquimod treatment should be continued up to 8 weeks until the disappearance of the warts.
If 5% cream is prescribed, apply Imiquimod topical cream onto the affected area thrice per week, before bedtime. The cream should be left untouched for 6-10 hours. The treatment should not exceed more than 16 weeks.
 
For Basal Cell Carcinoma (Adults):
For the treatment of biopsy-confirmed superficial basal cell carcinoma, apply 5% of cream topically, at least 5 times per week for 6 weeks. The applied cream should be left untouched for at least 8 hours. For tumor with diameter 0.5-1.0 cm, approximately 10 mg of 5% cream should be applied. For tumors more than or equal to l-1.5 cm, 25 mg of 5% cream should be applied. Tumors with target size more than or equal to 1.5 to 2 cm, apply 40 mg of 5% Imiquimod cream.
 
For Molluscum Contagiosum (Adults):
Indication not approved by USFDA

For Condylomata Acuminata (Adults):
12 years or older:
In individuals, 12 years and older, If 3.75% creams are prescribed, a thin layer of topical cream should be applied onto the external genital/perianal warts, once a day. After each application rub the applied area gently. The layer should be left untouched for at least 8 hours. The treatment should be continued for 8 weeks.

If 5% cream is prescribed, apply Imiquimod topical cream onto the external genital/perianal area thrice a week, before bedtime. After each application rub the applied area gently. The layer should be left untouched for at least 8 hours. The treatment should be continued for 16 weeks.
 
For Molluscum Contagiosum (Pediatric):
The effectiveness of Imiquimod is not studied in clinical trials, and the indications are not approved by USFDA.

Food(before/after)

Information not available

List of Contraindications

Imiquimod and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult your doctor if you are in gestation or planning to have a baby during Imiquimod treatment.

Imiquimod and Lactation

Nursing mothers should consult the healthcare provider before Imiquimod treatment.

Imiquimod and Children

Imiquimod is contraindicated in children younger than 12 years of age. Treatment of genital warts in patients is approved only in patients over 12 years of age. For other indications, the patient should be at least 18 years old.

Imiquimod and Geriatic

Information not available

Imiquimod and Other Contraindications

Information not available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

Imiquimod brands in India:

Imiquad Nilwart

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